Research
‘Ideal’ cardiovascular health helps people live longer – study

A large-scale observational study from China has demonstrated the link between ideal behavioural and medical cardiovascular factors and lower mortality rates.
Cardiovascular disease (CVD) is one of the greatest contributors to global deaths.
According to the American Heart Association (AHA), ideal cardiovascular health (ICH) is determined by a combination of seven behavioural and medical factors; no smoking, a body mass index (BMI) below 23 kg/m2, adequate physical activity, a balanced diet, total cholesterol of less than 200 mg/dL, blood pressure below 120/80 mm Hg and fasting glucose under 100 mg/dL.
Although these factors have been linked to reduced rates of mortality, studies in Asian populations have been limited.
How the behavioural and medical factors interact with each other is also poorly understood and as a result intervention programmes for CVD in Asian countries like China have been hampered.
A study, published in the Chinese Medical Journal, sought answers to these challenges.
To ensure adequate representation of the Chinese population, the researchers pooled data from three study cohorts encompassing almost 200,000 individuals and examined the association between ICH and death due to different causes.
In total, the study included 198,164 Chinese adults from the China Kadoorie Biobank study (2004–2018), Dongfeng-Tongji cohort (2008–2018), and Kailuan study (2006–2019).
To remove possible bias, only participants without CVD and cancer at the start of the study were included. Each participant was scored based on their performance on the seven behavioral and medical parameters (poor performance being scores as 0; intermediate performance as one; and ideal performance as two).
Accordingly, the highest possible behavioural score was eight, while the highest possible medical score was six. By adding these scores, a 14-point ICH score was computed. This ICH score was then weighed against death due to any cause (all-cause mortality), CVD, respiratory dysfunction, and cancer.
Through its large sample size and follow-up durations, the study achieved an overall follow-up period of around 2 million person-years.
During this period, compared to those with an ICH score of 0–6, individuals with ICH scores of 10–14 had an approximately 50 per cent lower risk of all-cause, CVD, and respiratory mortality.
This suggested that ICH is associated with lower all-cause, CVD, and respiratory mortality among Chinese adults.
Interestingly, although there was no interaction between medical and behavioural factors, higher behavioural and medical scores were both independently associated with lower rates of all-cause and CVD mortality. However, only higher behavioural health scores were associated with lower rates of death due to cancer and respiratory dysfunction.
Corresponding author Dr An Pan, a Professor of Epidemiology at the School of Public Health, Tongji Medical College, explained: “To prevent premature death, it is imperative to identify population-specific determinants of health. The goal was to examine these factors in a Chinese population and provide an impetus for improving healthcare management in China.”
Shedding light on the importance of these findings, Dr Shouling Wu of Kailuan Hospital, also a corresponding author on this study, added: “The results of this study are powered by a large sample size, the use of multiple patient cohorts, and the long-term follow-up. They are consistent with the results of previous studies from western populations and provide a much clearer roadmap for premature death prevention in the Chinese population.”
Indeed, the findings show that both behavioural and medical health parameters need to be targeted in order to prevent premature deaths in China. Individuals should try to maintain healthy lifestyles and cardiometabolic conditions, and policies that aid this goal should be developed.
While additional studies are needed to validate the association of ICH with non-CVD mortality or mortality due to different subtypes of CVD and to explore unseen interactions between behavioural and medical parameters, this study attests to the power of individual lifestyle behaviours in prolonging one’s lifespan and potentially one’s quality of life
Research
NHS to review cost effectiveness of new Alzheimer’s drugs

NICE will review whether new Alzheimer’s drugs should be offered on the NHS after an appeal found their wider impact was not fully counted.
An appeal found that the National Institute for Health and Care Excellence had failed to properly account for the wider impact of the treatments, including the heavy burden on unpaid carers, when calculating the cost effectiveness of the medicines.
Both treatments, lecanemab and donanemab, will now return to a NICE committee for further consideration.
“Today’s ruling is an opportunity for NICE to consider the real cost of Alzheimer’s on people and their families, and we welcome the decision to look again at whether new medicines could be provided on the NHS,” said David Thomas, head of policy and public affairs at Alzheimer’s Research UK.
Lecanemab and donanemab do not cure Alzheimer’s, but they slow it by targeting and clearing clumps of amyloid proteins, sticky protein build-ups in the brain linked to the disease.
While the drugs are available privately in the UK for people who can afford them, NICE ruled last year that they were too expensive to be made available on the NHS in England and Wales.
It is estimated informal dementia care costs the economy more than £20bn a year.
Alzheimer’s Research UK wants NICE to update how it assesses the value of new dementia drugs and factor in the huge additional costs this condition places on society and the wider economy.
NICE and its expert committees assess whether new drugs are good value for money for the NHS based on a wide range of evidence.
This includes how treatments perform in clinical trials, the experiences of patients and carers, and the costs of new drugs as well as any changes to NHS services needed to provide access.
When NICE weighs up whether a new Alzheimer’s drug is cost effective for the NHS, it carries out a limited assessment of the impact dementia has on the health of carers.
But the condition takes an enormous toll on families and society because caring for someone with dementia can lead people to become more isolated and give up work.
It can have a major emotional impact and put families under financial strain.
Thomas said: “Research has delivered new treatments with the potential to provide people with valuable extra months of independence, lessening the burden on carers.
“While these treatments offer modest benefits and can cause serious side effects, they provide the foundation for a future where dementia becomes a treatable condition.
“Now we need NICE to look again at how these medicines could benefit both people with early Alzheimer’s and their carers.”
Chris, whose mother Shirley is living with Alzheimer’s disease, said: “The real cost of Alzheimer’s is far greater than many people realise.
“In order to give my mum the care she needed, I moved back home to help my dad as the care was too much for him alone. After my dad passed away from Covid in 2021, I became sole carer for my mum.
“It was a very difficult period, working a full-time job, caring for Mum and dealing with the loss of my dad. Eventually I got some in-home care support to help.
“The family has borne most of the cost of Mum’s care, both in time and fees, and the family home has been sold to finance it.”
“The emotional and financial strain Alzheimer’s has taken on our family is horrendous, and I know many families across the UK are experiencing this pressure.”
He is backing Alzheimer’s Research UK’s call for NICE to change how it evaluates new dementia treatments.
The timeframe for the next NICE meetings to discuss the drugs is still to be set, and it is not certain follow-up hearings would change NICE’s guidance on access to the medicines.
But Alzheimer’s Research UK is continuing to push to make sure dementia is now a main priority for political and NHS decision-makers.
The head of the ongoing independent review into adult social care, Baroness Louise Casey, has called on the government to act, show leadership and prioritise dementia.
She has proposed appointing a dementia tsar to drive forward the prevention, treatment and care of dementia.
Baroness Casey has also argued for more funding for dementia treatment trials.
With more than 130 Alzheimer’s drugs in clinical trials worldwide, the charity says it is vital the NHS runs trials of new treatments now to understand how to deliver them to eligible patients in future.
In addition to changing how NICE assesses new medicines, the health service needs to collect real-world evidence on new dementia drugs and prepare for diagnostic tests and innovative treatments that are coming.
“Alzheimer’s Research UK is calling on the government to give dementia the same political determination that transformed cancer care,” Thomas said.
“We urgently need investment and a clear UK-wide plan so new treatments can be assessed in the NHS and reach the people who stand to benefit.”
Health and social care secretary Wes Streeting has said dementia is “one of the greatest challenges of our time” and pledged that the UK should become a world leader in dementia clinical trials.
News
Osteoporosis drugs could reduce dementia risk, study suggests
News
Gut health supplement relieves arthritis pain, research finds

A prebiotic fibre supplement may ease arthritis pain and improve grip strength in people with knee osteoarthritis, a study suggests.
The daily supplement, made from inulin, a dietary fibre found in chicory root, Jerusalem artichokes and other vegetables, also lowered pain sensitivity and saw fewer people drop out than a digital physiotherapy programme tested alongside it.
Dr Afroditi Kouraki, lead author of the study from the University of Nottingham, said: ‘Our findings suggest that targeting gut health with a prebiotic supplement is a safe, well-tolerated, and effective way to reduce pain in people with knee osteoarthritis.
“The very low dropout rate compared to the exercise group is also encouraging from a public health perspective, people were able to fit this supplement easily into their daily lives.’
Osteoarthritis of the knee, a wear-and-tear joint condition, affects hundreds of millions of people worldwide and is a leading cause of pain and disability, particularly in older adults.
Current treatments rely heavily on pain medication, which can cause side effects, or exercise programmes, which many patients find hard to maintain.
The INSPIRE trial, led by researchers at the University of Nottingham, involved 117 adults with knee osteoarthritis and tested four groups: inulin alone, digital physiotherapy-supported exercise alone, a combination of both, and a placebo. Both inulin and physiotherapy independently reduced knee pain.
However, inulin alone improved grip strength and reduced pain sensitivity, measures linked to how the nervous system processes pain, while physiotherapy did not.
The dropout rate for those taking the supplement was just 3.6 per cent, compared with 21 per cent for the physiotherapy group, suggesting a daily supplement may be easier for people to stick with than an exercise programme.
Inulin works as a prebiotic, meaning it feeds beneficial bacteria in the gut.
This leads to the production of compounds called short-chain fatty acids, particularly butyrate, which can affect inflammation and pain pathways throughout the body.
Participants taking inulin also showed increased levels of both butyrate and GLP-1, a gut hormone linked to pain regulation and muscle health.
Higher GLP-1 levels were associated with improved grip strength, pointing to a possible gut-muscle connection.
Senior author Professor Ana Valdes added: ‘The link we observed between GLP-1 and grip strength is particularly intriguing and points to a broader gut-muscle-pain axis that warrants further investigation. This could have implications not just for osteoarthritis, but for understanding how gut health influences ageing and physical resilience more broadly.’
Professor Lucy Donaldson, director of research at Arthritis UK, said: “The pain of arthritis can severely impact quality of life. Our recent lived experience survey showed that six in ten people are living in pain most or all of the time due to their arthritis.
“Researchers are starting to explore the role of the gut microbiome in our experience of pain.
“This exciting preliminary research highlights how diet and physiotherapy can act in different ways to have benefits for people with arthritis.
“We know a variety and balance of healthy foods, including fibre, and regular physical activity matter, and we’re glad to be supporting research that explores how they work to help people with arthritis.”













