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CT scan can reveal immune system ageing, research finds

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The thymus, a small and relatively unknown organ, may play a bigger role in the immune system of adults than was previously believed, according to a recent study.

Researchers from Linkoping University in Sweden have found that with age, the glandular tissue in the thymus is replaced by fat and the level of its degeneration reflects the ageing of the immune system.

The rate at which this happens is linked to sex, age and lifestyle factors, the study found.

“We doctors can assess the appearance of the thymus from largely all chest CT scans, but we tend to not see this as very important,” said researcher Mårten Sandstedt of the Faculty of Medicine and Health Sciences.

“But now it turns out that the appearance of the thymus can actually provide a lot of valuable information that we could benefit from and learn more about.”

Fatty degeneration

The thymus is a gland located in the upper part of the chest. It has been long known that this small organ is important for immune defence development in children.

After puberty, the thymus decreases in size and is eventually replaced by fat, in a process known as fatty degeneration.

This has been taken to mean that it loses its function, which is why the thymus has for a long time been considered as being not important in adult life.

This view has however been challenged in some minor research studies that indicate that having an active thymus as an adult may be an advantage and could provide increased resilience against infectious disease and cancer.

Only very few studies so far have examined the thymus in adults.

In the latest study, published in Immunity & Ageing, the researchers examined the thymus’ appearance in chest CT scans of more than 1,000 Swedish individuals aged 50 to 64.

They were participating in the large SCAPIS study, which includes both extensive imaging and comprehensive health assessments including lifestyle factors, such as dietary habits and physical activity.

In their sub-study of SCAPIS, the researchers also analysed immune cells in the blood.

“We saw a huge variation in thymus appearance,” Sandstedt said.

“Six out of ten participants had complete fatty degeneration of thymus, which was much more common in men than in women, and in people with abdominal obesity.

“Lifestyle also mattered. Low intake of fibres in particular was associated with fatty degeneration of thymus.”

Immune system

The Linköping researchers’ study provides new knowledge by associating thymus appearance with lifestyle and health factors, and the immune system.

In the development of the immune system, the thymus acts like a school for a type of immune cells known as T-cells.

This is where the T-cells learn to recognise bacteria, viruses and other things that are alien to the body.

They also learn to be tolerant and not attack anything that is part of the person’s own body, which could otherwise lead to various autoimmune diseases.

Researchers saw that individuals with fatty degeneration of the thymus showed lower T-cell regeneration.

“This association with T-cell regeneration is interesting. It indicates that what we see in CT scans is not only an image, it actually also reflects the functionality of the thymus,” said researcher Lena Jonasson.

“You can’t do anything about your age and your sex, but lifestyle-related factors can be influenced. It might be possible to influence immune system ageing.”

But more research is needed before it will be possible to know whether thymus appearance, and thereby immune defence ageing, will have any implications for general health.

The researchers are now moving on to follow-up studies of the thymus of all 5,000 participants in SCAPIS Linköping to see whether CT scan thymus images can provide information on future risk of disease.

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World’s “most advanced” preventative and diagnostics clinic aims to extend human lifespan

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Biograph's new clinic in the US.

Longevity author and pioneer Peter Attia has co-founded a new US health and diagnostics clinic which aims to advance human lifespan.

Biograph, co-founded with John Hering, has opened what it calls “the world’s most advanced preventative health and diagnostics clinic” in the San Francisco Bay Area with plans to expand globally and open its second clinic in New York City later this year.

It aims to enable members to take full control of their health by assessing risk and insights across five critical health pillars: atherosclerotic cardiovascular disease, metabolic dysfunction, brain health and neurodegenerative disease, cancer risk and early detection, and quality of life metrics.

Attia, author of Outlive: The Science and Art of Longevity, says: “Diagnostics are foundational to evaluating and implementing an effective health strategy informed by a systems-based approach, as well as comprehensive analyses that consider each data point within the context of an individual’s entire health picture.

“Biograph’s evaluation is best in class, which is why I recommend my patients start here.”

Co-founder John Hering says: “Inspired by one of my best friend’s cancer diagnosis, Biograph was founded on the belief that with the proper application of advanced medical technology and early detection, we can save lives.

“There is no greater investment we can make in the future, as individuals or humanity, than in our health. With an approach rooted in scientific evidence, Biograph is poised to be an integral catalyst helping to redefine what it means to live a better and longer life.”

The preventive healthcare market is expected to reach US$773.1bn by 2034, driven in part by the paradigm shift away from a traditional treatment-focused health system to one that supports prevention and proactively identifies the root causes of aging.

Biograph’s assessment protocol has been developed with support from Dr Michael Doney, an emergency medicine physician turned precision longevity clinician and researcher.

He says: “My transition from emergency medicine to the preventive health field stemmed from a conviction that patients deserve a more comprehensive understanding of their health and well-being. Recognising the variability in quality among health tests, scans, and assessments, I was drawn to Biograph’s mission.

“We are committed to providing the most in-depth analysis of a broad range of health factors, enabling members to not only extend their lifespan but, more importantly, to optimise their healthspan and overall quality of life.”

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New intervention for frail older people shows promise

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A new UK service aimed at supporting older people who are starting to become frail, could reduce emergency hospital admissions by more than a third and save the NHS money.

The results from the clinical trial, published in The Lancet Healthy Longevity and funded by the National Institute for Health and Care Research (NIHR), evaluated the effect and cost-effectiveness of a new service, consisting of six personalised home-based visits from a support worker, tailored to each person to identify what they need to stay well and independent.

Interventions could include home exercise programmes, nutritional support to improve energy levels, improving mental wellbeing and increasing social connections.

The researchers tested the service with 388 people, who were over the age of 65 and assessed as having “mild frailty”, across three areas of the UK (London, Hertfordshire and Yorkshire). Of these participants, 195 people were randomly allocated to receive the service, while 193 received their usual care, with no additional support.

Frailty is when someone is less able to recover after a health problem. It is common in people over 65 and increases disability, hospitalisations and care needs.

Participants in the trial were followed up for one year.

The researchers found that people who received the service had a 35% reduction in unplanned hospital admissions, leading to an average saving of £586 per person to the NHS over the year of the study.

Lead author, Professor Kate Walters (UCL Epidemiology & Health Care) said: “We developed the new service in partnership with experts, older people and carers, with the hope of helping people with mild frailty to maintain their independence and stay healthy for longer.

“We found that by providing personalised home-based support to those in need, we can significantly reduce emergency hospital admissions and potentially free up hospital resources. Our study demonstrates the impact of tailored interventions on maintaining independence and improving overall well-being.”

The researchers found that there were additional benefits to the service, including small improvements in wellbeing, psychological distress and frailty score.

However, the new service didn’t improve levels of independence in self-care.

NIHR Health Technology Assessment (HTA) programme director, Andrew Farmer, said: “The HomeHealth intervention can help older adults with mild frailty stay independent, improving quality of life and overall well-being, while reducing hospital and care costs.

“By addressing key factors like strength, nutrition, and social engagement, it can reduce deterioration and the need for intensive support.

“High quality research such as this is an important part of improving future health and care practice.”

With the right funding and support, the researchers hope the service could be available to patients across the country within two years.

Professor Walters added: “By investing in preventative measures, the health service may be able to reap benefits of savings elsewhere in the system.”

The research was carried out in collaboration with Age UK.

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Increased mortality in countryside compared to city

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Increased mortality in countryside compared to city

A new study of nearly a million emergency admissions in Norway has found increased mortality in the elderly who live in the countryside compared to those that live in the city.

Research shows that elderly people living in rural areas have higher mortality rates if they are discharged to a municipality under pressure. Additionally, the research found that elderly people over the age of 70 who live in a municipality with fewer than 10,000 inhabitants are particularly vulnerable.

The research has been carried out in light of the growing population in Norway which is set to see 250,000 more Norwegians over the age of 80.

The study

Gudrun Maria Waaler Bjørnelv, associate professor of Health Economics at NTNU, is concerned that municipal authorities in Norway may not be prepared for an ageing population.

Working with a research team from NTNU, St. Olavs Hospital, Trondheim Municipal Authority and SINTEF, Bjørnelv has studied all Norwegians over the age of 70 who were admitted to emergency departments from 2012 to 2016, which amounted to just over 350,000 people.

This group of elderly people had almost 900,000 emergency hospital admissions during this period. The researchers followed them for 30 days after the day they were admitted.

Nursing and care services that were under pressure led to increased mortality in elderly who were under their care, and that elderly people in small municipalities had the highest mortality rate.

A small municipality was defined as having fewer than 10,000 inhabitants. According to Statistics Norway, 70% of Norwegian municipalities in 2016 had fewer than 10,000 inhabitants. In total, 17% of the population lives in a small municipality.

Bjørnelv stated: “Previously, it was thought that small municipalities do better than large municipalities, because they have fewer patients in hospitals waiting to be discharged to the municipal services.

“Our findings, however, indicate that small municipalities are more vulnerable during periods when the demand for nursing and care services is higher than the municipality can supply.”

“We need to take a closer look at the municipal services, and it needs to happen now.”

Bjørnelv points out that small municipalities may experience more pressure regarding demand for available nursing home places and health professionals.

“This may make them more vulnerable to fluctuations and pressure on health services,” Bjørnelv said.

To investigate how mortality rates among patients changed, the researchers relied on information regarding the amount of pressure individual municipalities were under.

“If there is a build-up of patients who are ready to be discharged from hospital to one municipality, this suggests that the municipal services such as home care and nursing homes are under pressure. It shows that they do not have the capacity to receive these patients,” stated Bjørnelv.

The study investigated how mortality rates changed if people were admitted to emergency departments during periods of increased pressure in the municipality. That would be during periods where many people from the same municipality as the acutely admitted patient were waiting to be discharged from hospital.

“Is there a greater tendency to move some people home after hospitalisation rather than to a municipal short-term care facility if the municipality is under pressure? Is it better for elderly people from a pressured municipality to longer in the hospital – without the municipality having to pay a ‘fine’ to the hospital? What is best for the patient?” Bjørnelv said.

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